What is the best and cheapest way to get from Europe, Italy in specific, to Quito, Ecuador?

Iberia (our of Madrid) and KLM (out of Amsterdam) offer the only non-stop flights to Quito from Europe. You can also try flying Iberia to Miami and then connecting with American Airlines to Quito.

Other connecting options include:

* LAN Chile (Frankfurt/Madrid), connect in Santiago with LAN Ecuador

* Avianca (Madrid), connect in Bogota with Avianca

* Continental Airlines (Rome/Milan), then connect in Houston or Newark with Continental

* Delta (Rome/Milan), connect in New York with LAN Ecuador

look on expedia.com and cheaptickets.com

The best way is either KLM from Amsterdam or Iberia from Madrid. An alternative might be American Airlines through Miami.
Being it's low season now, I am sure all offer same or similar costs at present.

I would try www.ytbtravel.com/gordonsa they are very cheap for international travel.

Good Luck in your search

Cheapest:
USD1384 with AA

Shortest:
USD3645 with Iberia

check:
http://www.dohop.com/

http://www.1800flyeurope.com/

http://www.bezurk.com/flights/

http://www.bookingbuddy.com/

http://www.kayak.com/

http://www.mobissimo.com/search_airfare....

http://www.momondo.com/en/

if ready for a round-the-world tour, check:

http://www.airtreks.com/

I would suggest KLM or IBERIA, sometimes AA have good promotions as well, if you would like to see Quito then tried the high or low season as well, then you can find reasonable prices, now Delta is flying as well making an stop in Atlanta, then non stop to Quito or GUAYAQUIL whatever your destination in Ecuador might be, all of the International flights make an stop either in Quito then go to Guayaquil.

swim!